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Actinonin

CAT: 0013-GTR19154274-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19154274-02Size:5 mg
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Description
Actinonin ((-) -Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities.
CAS Number
13434-13-4
Field of Research
Cell Biology
Purity
>98%
Bioactivity
Leucyl aminopeptidase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml) .
Smiles
CCCCCC (CC (=O) NO) C (=O) NC (C (C) C) C (=O) N1C (CO) CCC1
Molecular Formula
C19H36N3O5
Molecular Weight
385.51
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
3-[[1-[-2-Hydroxymethyl) -1-pyrrolidinyl) carbonyl]-2-methylpropyl]carbamoyl]-octanohydroxamic acid

Chemical Information

Actinonin

actinonin has been reported in Streptomyces with data available.

CAS Number13434-13-4
PubChem CID443600
IUPAC Name(2R)-N'-hydroxy-N-[(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-pentylbutanediamide
Molecular FormulaC19H35N3O5
Molecular Weight385.5
XLogP1.5
Topological Polar Surface Area119
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count11
Heavy Atom Count27
Formal Charge0
Complexity498
SMILES
CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO
InChI
InChI=1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)/t14-,15+,17+/m1/s1
InChIKey
XJLATMLVMSFZBN-VYDXJSESSA-N
Chemical Structure
2D Structure
2D structure of Actinonin
CAS: 13434-13-4
CID: 443600
Formula: C19H35N3O5
MW: 385.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight385.5
XLogP31.5
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count11
Exact Mass385.25767123
Monoisotopic Mass385.25767123
Topological Polar Surface Area119 Ų
Heavy Atom Count27
Formal Charge0
Complexity498
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
FA17212-01(-) -Actinonin
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