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AZD 4205

CAT: 0013-GTR19154029-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19154029-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD 4205 (AZD4205) is a potent, selective JAK1 inhibitor IC50 of 73 nM and Ki of 2.8 nM, shows high selectivity against JAK2 and JAK3 with IC50 of 13,233 nM and > 30,000 nM respectively; shows potent inhibition of p-STAT3 in a cell based assay of JAK1 activity with an IC50 of 128 nM and excellent selectivity across the kinome; reduces residual disease and prolongs the benefit of Osimertinib in lung cancer patients with EGFR activating mutations both in vitro and in vivo.
CAS Number
2091134-68-6
Purity
>98%
Smiles
O=C ([C@@H] (C) N1CCN (C) [C@H] (C) C1) NC2=CC=CC3=C2NC=C3C4=C (F) C=NC (NC5=CN (C) N=C5OC) =N4
Molecular Formula
C25H31N9O2
Molecular Weight
521.601
Notes
For research use only.

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