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ML364 (Standard)

CAT: 0804-HY-100900RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-100900RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML364 (Standard) is the analytical standard of ML364 (HY-100900) . This product is intended for research and analytical applications. ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC50=1.1 μM) with anti-proliferative activity, which direct binds to USP2 (Kd=5.2 μM), induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP[1][2].
CAS Number
[1991986-30-1]
Target
Deubiquitinase; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
O=C(NC1=NC(C2=CC=CC=C2)=CS1)C3=CC=C(C(F)(F)F)C=C3NS(=O)(C4=CC=C(C)C=C4)=O
Molecular Formula
C24H18F3N3O3S2
Molecular Weight
517.54
References & Citations
[1]Davis MI, et al. Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models. J Biol Chem. 2016 Nov 18;291 (47) :24628-24640.|[2]Hashimoto M, et al. Inhibition of ubiquitin-specific protease 2 causes accumulation of reactive oxygen species, mitochondria dysfunction, and intracellular ATP decrement in C2C12 myoblasts. Physiol Rep. 2019 Jul;7 (14) :e14193.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

CatalogName
456382-01ML364
A20371-5ML364 5mg
A20371-10ML364 10mg
A20371-50ML364 50mg
A20371-500ML364 500mg
A20371-25ML364 25mg
A20371-100ML364 100mg
A20371-10mM-DML364 10mM * 1mL in DMSO
abx098968-01Standard

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