JAK2/FLT3-IN-3

• UNSPSC Description:

  JAK2/FLT3-IN-3 (11r) is a dual FLT3 and JAK2 inhibitor, with IC50 values of 2.01 nM, 0.51 nM and 104.40 nM for JAK2, FLT3 and JAK3, respectively. JAK2/FLT3-IN-3 (11r) induces apoptosis and possesses antitumor activity[1].

• Target Antigen:

  Apoptosis; FLT3; JAK

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/jak2-flt3-in-3.html

• Smiles:

  O=C(NC1=CC=C(C(C)=O)C=C1)N(CC2)CCN2C3=NC(NC4=CC=C(N5CCC(N6CCN(C)CC6)CC5)C=C4)=NC=C3C

• Molecular Weight:

  611.78

• References & Citations:

  [1]Sicong Xu, et al. 2-Aminopyrimidine derivatives as selective dual inhibitors of JAK2 and FLT3 for the treatment of acute myeloid leukemia. Bioorg Chem. 2023 May:134:106442.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3038183-53-5