VRT-532

VRT-532

• Product Name Alternative: Vatensol
• CAS Number: 38214-71-0
• UNSPSC Description: VRT-532 (CFpot-532) is a potent is a potent CFTR modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis[1][2].
• Target Antigen: CFTR
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/vrt-532.html
• Purity: 98.98
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: OC(C=CC(C)=C1)=C1C2=NNC(C3=CC=CC=C3)=C2
• Molecular Weight: 250.30
• References & Citations: [1]Pasyk S, et al. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem J. 2009 Feb 15;418(1):185-90. |[2]Wang Y, et al. Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein. J Biol Chem. 2007 Nov 16;282(46):33247-33251.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported