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TAT-PiET-PROTAC

CAT: 0013-GTR19144447-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19144447-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TAT-PiET-PROTAC is a TAT-PiET modified by a proteolysis targeting chimera (PROTAC) . TAT-PiET is a cell-penetrating peptide that targets the extra-terminal (ET) domain of BRD4. TAT-PiET-PROTAC disrupts the interaction between BRD4 and the oncogene JMJD6 in breast cancer, effectively inhibiting the growth of these cancer cells. Additionally, it combats endocrine resistance in ERα-positive breast cancer cells, making it a promising breast cancer inhibitor. TAT-PiET-PROTAC is also utilized in the synthesis/research of radiolabeled conjugate drugs (RDC) .
Field of Research
Epigenetics & Chromatin, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.

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