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Phosphonoacetic acid

CAT: 0804-HY-128744-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128744-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Phosphonoacetic acid is an endogenous metabolite and antiviral agent. Phosphonoacetic acid is active against orthopoxviruses and herpes viruses. Phosphonoacetic acid can inhibit HSV DNA synthesis and virus-specific DNA polymerase activity, and affect the synthesis of late viral proteins[1][2].
CAS Number
4408-78-0
UNSPSC
12352211
Hazard Statement
H314
Target
DNA/RNA Synthesis; Endogenous Metabolite; HSV; Orthopoxvirus
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/phosphonoacetic-acid.html
Purity
98.0
Solubility
H2O : 260 mg/mL (ultrasonic)
Smiles
O=C(O)CP(O)(O)=O
Molecular Formula
C2H5O5P
Molecular Weight
140.03
Precautions
H314
References & Citations
[1]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57 (1-2) :41-52. |[2]Honess RW, et al. Herpes simplex virus resistance and sensitivity to phosphonoacetic acid. J Virol. 1977 Feb;21 (2) :584-600.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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