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M1002

CAT: 0804-HY-139287-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139287-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors[1].
CAS Number
823830-85-9
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m1002.html
Concentration
10mM
Purity
99.69
Solubility
DMF : 50 mg/mL (ultrasonic) |DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S1(N=C(C2=C1C=CC=C2)NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O
Molecular Formula
C15H8F6N2O2S
Molecular Weight
394.30
References & Citations
[1]Dalei Wu, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Apr;15 (4) :367-376.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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