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M1001

CAT: 0804-HY-111547-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111547-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M1001 is a weak hypoxia-inducible factor-2α (HIF-2α) agonist. M1001 can bind to the HIF-2α PAS-B domain, with a Kd of 667 nM. M1001 can be used in chronic kidney disease research[1].
CAS Number
874590-32-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/M1001.html
Purity
99.51
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=S1(C2=C(C=CC=C2)C(NC3=C(N4CCCC4)C=CC=C3)=N1)=O
Molecular Formula
C17H17N3O2S
Molecular Weight
327.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Wu D, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Feb 25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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