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L-006235

CAT: 0804-HY-103352-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103352-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-006235 (L-235) is a potent, selective, reversible and orally active inhibitor of cathepsin K, with an IC50 of 5 nM in bone resorption assay. L-006235 shows selectivity for cathepsin K (Ki=0.2 nM) over cathepsin B, cathepsin L, and cathepsin S (Ki=1, 6, and 47 μM, respectively) . L-006235 can reduce collagen degradation and prevent bone loss[1][2].
CAS Number
294623-49-7
Product Name Alternative
L-235
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/l-006235.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1(C(NCC#N)=O)CCCCC1)C2=CC=C(C3=CSC(N4CCN(C)CC4)=N3)C=C2
Molecular Formula
C24H30N6O2S
Molecular Weight
466.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Palmer JT, et, al. Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. J Med Chem. 2005 Dec 1;48 (24) :7520-34.|[2]Falgueyret JP, et, al. Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. J Med Chem. 2005 Dec 1;48 (24) :7535-43.|[3]Pennypacker BL, et, al. Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbits. J Bone Miner Res. 2011 Feb;26 (2) :252-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin B; Cathepsin K

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Alternative Products

CatalogName
M22746-01L 006235
GTR19173935-01L-006235
A15302-200L 006235 200mg
A15302-50L 006235 50mg
A15302-10L 006235 10mg
A15302-100L 006235 100mg
A15302-25L 006235 25mg
A15302-5L 006235 5mg
A15302-2L 006235 2mg
A15302-10mM-DL 006235 10mM * 1mL in DMSO

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