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8-Deoxygartanin

CAT: 0804-HY-N6009-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6009-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) [1]. 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum[2]. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM[3].
CAS Number
33390-41-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
NF-κB; Parasite
Type
Natural Products
Related Pathways
Anti-infection; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/8-deoxygartanin.html
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C/C(C)=C\CC1=C(O)C(C/C=C(C)/C)=C(O)C(C(C2=CC=C3)=O)=C1OC2=C3O
Molecular Formula
C23H24O5
Molecular Weight
380.43
Precautions
H302, H315, H319
References & Citations
[1]Khaw KY, et al. Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies. Phytomedicine. 2014 Sep 25;21 (11) :1303-9.|[2]Ngouamegne ET, et al. Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides. Chem Pharm Bull (Tokyo) . 2008 Mar;56 (3) :374-7.|[3]Han AR, et al. Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen) . J Nat Prod. 2009 Nov;72 (11) :2028-31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Plasmodium; RelA/p65

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