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Pardoprunox (hydrochloride)

CAT: 0804-HY-14958A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14958A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pardoprunox (SLV-308) hydrochloride is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively[1].
CAS Number
269718-83-4
Product Name Alternative
SLV-308 hydrochloride; DU-126891 hydrochloride
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Pardoprunox-hydrochloride.html
Purity
99.46
Solubility
DMSO : 150 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
O=C1OC2=C(N3CCN(C)CC3)C=CC=C2N1.[H]Cl
Molecular Formula
C12H16ClN3O2
Molecular Weight
269.73
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Glennon JC, et al. In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2 (3H) -benzoxazolone, monohydrochloride) : a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist. Synapse. 2006 Dec 15;60 (8) :599-608.|[2]Jones CA, et al. An in vivo pharmacological evaluation of pardoprunox (SLV308) --a novel combined dopamine D (2) /D (3) receptor partial agonist and 5-HT (1A) receptor agonist with efficacy in experimental models of Parkinson's disease. Eur Neuropsychopharmacol. 2010 Aug;20 (8) :582-593.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT1 Receptor; D2 Receptor; D3 Receptor; mLAG-3

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