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Pardoprunox

CAT: 0804-HY-14958Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14958Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pardoprunox (SLV-308) is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively[1].
CAS Number
269718-84-5
Product Name Alternative
SLV-308; DU-126891
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Pardoprunox.html
Solubility
10 mM in DMSO
Smiles
O=C1OC2=C(N3CCN(C)CC3)C=CC=C2N1
Molecular Formula
C12H15N3O2
Molecular Weight
233.27
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Glennon JC, et al. In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2 (3H) -benzoxazolone, monohydrochloride) : a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist. Synapse. 2006 Dec 15;60 (8) :599-608.|[2]Bronzova J, et al. Double-blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease. Mov Disord. 2010 Apr 30;25 (6) :738-46.|[3]Bétry C, et al. In vivo effects of pardoprunox (SLV308), a partial D?/D? receptor and 5-HT1A receptor agonist, on rat dopamine and serotonin neuronal activity. Synapse. 2011 Oct;65 (10) :1042-51.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT1 Receptor; D2 Receptor; D3 Receptor; mLAG-3

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