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Losartan Potassium

CAT: 1299-RM-L192080-03Size: 50 mgDry Ice: NoHazardous: No
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CAT#:1299-RM-L192080-03Size:50 mg
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CAS Number
124750-99-8
Synonyms
Potassium 5- (4'- ((2-butyl-4-chloro-5- (hydroxymethyl) -1H-imidazol-1-yl) methyl) -[1,1'-biphenyl]-2-yl) tetrazol-1-ide
Molecular Formula
C22H22ClN6O K
Molecular Weight
421.91 39.10
Target Alternative Name
Losartan
Product Name Synonym
Potassium 5- (4'- ((2-butyl-4-chloro-5- (hydroxymethyl) -1H-imidazol-1-yl) methyl) -[1,1'-biphenyl]-2-yl) tetrazol-1-ide

Chemical Information

Losartan Potassium

Losartan Potassium is the potassium salt of losartan, a non-peptide angiotensin II receptor antagonist with antihypertensive activity. Losartan selectively and competitively binds to the angiotensin II receptor (type AT1) and blocks the binding of angiotensin II to the receptor, thus promoting vasodilatation and counteracting the effects of aldosterone. Converted from angiotensin I by angiotensin-converting enzyme (ACE), angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, decreasing sodium excretion and increasing potassium excretion, and acts as a vasoconstrictor in vascular smooth muscle.

CAS Number124750-99-8
PubChem CID11751549
IUPAC Namepotassium [2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Molecular FormulaC22H22ClKN6O
Molecular Weight461.0
Topological Polar Surface Area77.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Heavy Atom Count31
Formal Charge0
Complexity526
SMILES
CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+]
InChI
InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
InChIKey
OXCMYAYHXIHQOA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Losartan Potassium
CAS: 124750-99-8
CID: 11751549
Formula: C22H22ClKN6O
MW: 461.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight461.0
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Exact Mass460.1180685
Monoisotopic Mass460.1180685
Topological Polar Surface Area77.7 Ų
Heavy Atom Count31
Formal Charge0
Complexity526
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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