Losartan Potassium

CAT: 1299-RM-L192080-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:1299-RM-L192080-01Size:10 mg

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CAS Number

124750-99-8

Synonyms

Potassium 5- (4'- ((2-butyl-4-chloro-5- (hydroxymethyl) -1H-imidazol-1-yl) methyl) -[1,1'-biphenyl]-2-yl) tetrazol-1-ide

Molecular Formula

C22H22ClN6O K

Molecular Weight

421.91 39.10

Target Alternative Name

Losartan

Product Name Synonym

Potassium 5- (4'- ((2-butyl-4-chloro-5- (hydroxymethyl) -1H-imidazol-1-yl) methyl) -[1,1'-biphenyl]-2-yl) tetrazol-1-ide

Chemical Information

Losartan Potassium

Losartan Potassium is the potassium salt of losartan, a non-peptide angiotensin II receptor antagonist with antihypertensive activity. Losartan selectively and competitively binds to the angiotensin II receptor (type AT1) and blocks the binding of angiotensin II to the receptor, thus promoting vasodilatation and counteracting the effects of aldosterone. Converted from angiotensin I by angiotensin-converting enzyme (ACE), angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, decreasing sodium excretion and increasing potassium excretion, and acts as a vasoconstrictor in vascular smooth muscle.

CAS Number	124750-99-8
PubChem CID	11751549
IUPAC Name	potassium [2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Molecular Formula	C22H22ClKN6O
Molecular Weight	461.0
Topological Polar Surface Area	77.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Heavy Atom Count	31
Formal Charge	0
Complexity	526

SMILES

CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+]

InChI

InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1

InChIKey

OXCMYAYHXIHQOA-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 124750-99-8

CID: 11751549

Formula: C22H22ClKN6O

MW: 461.0

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	461.0
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Exact Mass	460.1180685
Monoisotopic Mass	460.1180685
Topological Polar Surface Area	77.7 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	526
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
RM-L192000-01	Losartan
RM-L192027-01	Losartan D4
RM-L192023-01	Losartan Impurity 3
RM-L192118-01	Losartan Impurity 42
RM-L192105-01	Losartan Impurity 28
RM-L192116-01	Losartan Impurity 40
RM-L192114-01	Losartan Impurity 38
RM-L192109-01	Losartan Impurity 33
RM-L192106-01	Losartan Impurity 29
RM-L192103-01	Losartan Impurity 26

Alternative Products

Catalog	Name
3798/50	Losartan potassium
HY-17512A-01	Losartan (potassium)

Losartan Potassium

Chemical Information

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