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Lomustine (Standard)

CAT: 0804-HY-13669R-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13669R-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lomustine (Standard) is the analytical standard of Lomustine. This product is intended for research and analytical applications. Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity.
CAS Number
13010-47-4
Product Name Alternative
CCNU (Standard) ; NSC 79037 (Standard)
UNSPSC
12352211
Target
Apoptosis; Autophagy; DNA Alkylator/Crosslinker; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lomustine-standard.html
Purity
99.94
Smiles
O=C(NC1CCCCC1)N(CCCl)N=O
Molecular Formula
C9H16ClN3O2
Molecular Weight
233.70
References & Citations
[1]Wang P, et al. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22;13 (11) :2353-2361.|[2]Harvey KA, et al. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. 2015 Mar;122 (3) :547-56.|[3]Yagiz K, et al. Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. Neuro Oncol. 2016 Oct;18 (10) :1390-401.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Launched

Chemical Information

Lomustine

1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) can cause cancer according to an independent committee of scientific and health experts. It can cause developmental toxicity according to state or federal government labeling requirements.

CAS Number13010-47-4
PubChem CID3950
IUPAC Name1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
Molecular FormulaC9H16ClN3O2
Molecular Weight233.69
XLogP2.8
Topological Polar Surface Area61.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count15
Formal Charge0
Complexity219
SMILES
C1CCC(CC1)NC(=O)N(CCCl)N=O
InChI
InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
InChIKey
GQYIWUVLTXOXAJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Lomustine
CAS: 13010-47-4
CID: 3950
Formula: C9H16ClN3O2
MW: 233.69
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight233.69
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass233.0931045
Monoisotopic Mass233.0931045
Topological Polar Surface Area61.8 Ų
Heavy Atom Count15
Formal Charge0
Complexity219
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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