Lomustine (Standard)

• Description :

  Lomustine (Standard) is the analytical standard of Lomustine. This product is intended for research and analytical applications. Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity.

• Product Name Alternative :

  CCNU (Standard) ; NSC 79037 (Standard)

• UNSPSC :

  12352211

• Target :

  Apoptosis; Autophagy; DNA Alkylator/Crosslinker; Reference Standards

• Type :

  Reference Standards

• Related Pathways :

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Others

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/lomustine-standard.html

• Purity :

  99.94

• Smiles :

  O=C(NC1CCCCC1)N(CCCl)N=O

• Molecular Formula :

  C9H16ClN3O2

• Molecular Weight :

  233.70

• References & Citations :

  [1]Wang P, et al. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22;13 (11) :2353-2361.|[2]Harvey KA, et al. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. 2015 Mar;122 (3) :547-56.|[3]Yagiz K, et al. Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. Neuro Oncol. 2016 Oct;18 (10) :1390-401.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C, sealed storage, away from light and moisture

• Scientific Category :

  Reference Standards

• Clinical Information :

  Launched

• CAS Number :

  [13010-47-4]