Lomustine

• UNSPSC Description:

  Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity.

• Target Antigen:

  Apoptosis; Autophagy; DNA Alkylator/Crosslinker

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Lomustine.html

• Smiles:

  O=C(NC1CCCCC1)N(CCCl)N=O

• Molecular Weight:

  233.70

• References & Citations:

  [1]Wang P, et al. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22;13(11):2353-2361.|[2]Harvey KA, et al. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. 2015 Mar;122(3):547-56.|[3]Yagiz K, et al. Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. Neuro Oncol. 2016 Oct;18(10):1390-401.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  13010-47-4