N1-Methylpseudouridine-5′-triphosphate (trisodium) solution (100mM)

N1-Methylpseudouridine-5′-triphosphate (trisodium) solution (100mM)

• UNSPSC Description: N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) trisodium solution (100mM) is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability[1].
• Target Antigen: DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog
• Type: Biochemical Assay Reagents
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/n1-methylpseudouridine-5-triphosphate-trisodium.html
• Purity: 99.0
• Solubility: H2O : ≥ 125 mg/mL
• Smiles: O[C@H]1[C@@H](O)[C@H](C(C(N2)=O)=CN(C)C2=O)O[C@@H]1COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
• Molecular Weight: 564.11
• References & Citations: [1]Andries O, Mc Cafferty S, De Smedt SC, Weiss R, Sanders NN, Kitada T. N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. J Control Release. 2015;217:337-344.
• Shipping Conditions: Dry Ice
• Storage Conditions: -80°C
• Clinical Information: No Development Reported