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Pseudouridine 5'-triphosphate (trisodium) solution (100mM)

CAT: 0804-HY-141567ASize: 5.5 mg (100 mM x 100 μL in Water)Dry Ice: NoHazardous: No
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CAT#:0804-HY-141567ASize:5.5 mg (100 mM x 100 μL in Water)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate. Pseudouridine 5'-triphosphate trisodium solution (100 mM) is substituted for UTP to improve the stability and translation efficiency of mRNA and reduce immunogenicity[1][2][3][4].
Product Name Alternative
Pseudo-UTP (trisodium) solution (100mM)
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pseudouridine-5-triphosphate-trisodium.html
Concentration
100 mM * 100 μL in Water
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=P(O)(O[Na])OP(OP(OC[C@H]1O[C@@H](C(C(N2)=O)=CNC2=O)[C@H](O)[C@@H]1O)(O[Na])=O)(O[Na])=O
Molecular Formula
C9H12N2Na3O15P3
Molecular Weight
550.09
References & Citations
[1]Muthian Shanmugasundaram, et al. An Efficient Protection-Free One-Pot Chemical Synthesis of Modified Nucleoside-5'-Triphosphates. Nucleosides Nucleotides Nucleic Acids. 2016 Jul 2;35 (7) :356-62. |[2]Steinle H, et al. Incorporation of Synthetic mRNA in Injectable Chitosan-Alginate Hybrid Hydrogels for Local and Sustained Expression of Exogenous Proteins in Cells. Int J Mol Sci. 2018 Apr 27;19 (5) :1313. |[3]Golombek S, et al. Intradermal Delivery of Synthetic mRNA Using Hollow Microneedles for Efficient and Rapid Production of Exogenous Proteins in Skin. Mol Ther Nucleic Acids. 2018 Jun 1;11:382-392.|[4]Khan A, et al. Pseudouridine in RNA: enzymatic synthesis mechanisms and functional roles in molecular biology. Int. J. Environ. Agric. Biotechnol, 2023, 8: 284-300.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

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