Pseudouridine 5'-triphosphate (trisodium) solution (100mM)

• UNSPSC Description:

  Pseudouridine-5’-triphosphate (Pseudo-UTP) trisodium solution (100mM) is one of the most commonly used modified nucleoside for the polymerase-mediated synthesis of RNA molecules. Compared with uridine-containing unmodified mRNAs, the application of pseudouridine-containing modified mRNAs exhibits better nuclease stability, immunogenicity, and translational properties[1]..

• Target Antigen:

  DNA/RNA Synthesis

• Type:

  Oligonucleotides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/pseudouridine-5-triphosphate-trisodium.html

• Purity:

  98.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O=P(O)(O[Na])OP(OP(OC[C@H]1O[C@@H](C(C(N2)=O)=CNC2=O)[C@H](O)[C@@H]1O)(O[Na])=O)(O[Na])=O

• Molecular Weight:

  550.09

• References & Citations:

  [1]Muthian Shanmugasundaram, et al. An Efficient Protection-Free One-Pot Chemical Synthesis of Modified Nucleoside-5'-Triphosphates. Nucleosides Nucleotides Nucleic Acids. 2016 Jul 2;35(7):356-62.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Solution, -20°C, 2 years

• Clinical Information:

  No Development Reported