Clobenpropit (dihydrobromide)
CAT:
804-HY-101198-06
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Clobenpropit (dihydrobromide)
- CAS Number: 145231-35-2
- UNSPSC Description: Clobenpropit dihydrobromide is a potent histamine H3R antagonist/inverse agonist with a pEC50 of 8.07 for histamine H3LR[1]. Clobenpropit dihydrobromide acts as partial agonist at histamine H4 receptors (Ki 13 nM). Clobenpropit dihydrobromide also binds to serotonin 5-HT3 receptors (Ki 7.4 nM) and α2A/α2C adrenoceptors (Ki 17.4/7.8 nM)[2]. Clobenpropit dihydrobromide increases apoptosis[3].
- Target Antigen: Apoptosis; Histamine Receptor
- Type: Reference compound
- Related Pathways: Apoptosis;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
- Applications: Cancer-programmed cell death
- Field of Research: Cancer; Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/clobenpropit-dihydrobromide.html
- Purity: 98.99
- Solubility: DMSO : 125 mg/mL (ultrasonic)
- Smiles: N=C(SCCCC1=CN=CN1)NCC2=CC=C(Cl)C=C2.[H]Br.[H]Br
- Molecular Weight: 470.65
- References & Citations: [1]Esbenshade TA, et al. Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects. J Pharmacol Exp Ther. 2003 Jun;305(3):887-96.|[2]Mena-Avila E, et al. Clobenpropit, a histamine H3 receptor antagonist/inverse agonist, inhibits [3H]-dopamine uptake by human neuroblastoma SH-SY5Y cells and rat brain synaptosomes. Pharmacol Rep. 2018 Feb;70(1):146-155.|[3]Paik WH, et al. Clobenpropit enhances anti-tumor effect of gemcitabine in pancreatic cancer. World J Gastroenterol. 2014 Jul 14;20(26):8545-57.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported