Clobenpropit
CAT:
804-HY-115447
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Clobenpropit
- CAS Number: 145231-45-4
- UNSPSC Description: Clobenpropit is a potent histamine H3-receptor antagonist. Clobenpropit decreases dopamine release and increases histamine levels in the hypothalamus. Clobenpropit shows antipsychotic-like activities. Clobenpropit causes a resuscitating effect in rats subjected to the hemorrhagic shock[1][2].
- Target Antigen: Histamine Receptor
- Type: Reference compound
- Related Pathways: GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
- Applications: Neuroscience-Neuromodulation
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/clobenpropit.html
- Solubility: 10 mM in DMSO
- Smiles: N=C(SCCCC1=CN=CN1)NCC2=CC=C(Cl)C=C2
- Molecular Weight: 308.83
- References & Citations: [1]Mahmood D, et al. The Effect of Subchronic Dosing of Ciproxifan and Clobenpropit on Dopamine and Histamine Levels in Rats. J Exp Neurosci. 2015 Aug 31;9:73-80.|[2]Wanot B, et al. Cardiovascular effects of H3 histamine receptor inverse agonist/ H4 histamine receptor agonist, clobenpropit, in hemorrhage-shocked rats. PLoS One. 2018 Aug 2;13(8):e0201519.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported