Bucumolol (hydrochloride)

• UNSPSC Description:

  Bucumolol hydrochloride is a β-adrenergic receptor antagonist that can slow heart rate (negative chronotropic effect) and reduce cardiac contractility (negative inotropic effect). Bucumolol hydrochloride has antiarrhythmic and local anesthetic activity and can be used in the study of cardiovascular diseases[1].

• Target Antigen:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/bucumolol-hydrochloride.html

• Smiles:

  O=C1C=CC2=C(C=CC(OCC(CNC(C)(C)C)O)=C2O1)C.Cl

• Molecular Weight:

  341.83

• References & Citations:

  [1]Nakayama, Koichi, et al. Antiarrhythmic activity of dextro-and levo-isomers OF 5-methyl-8-(2-hydroxy-3-t-butylamino-propoxy) coumarin hydrochloride (bucumolol), a β-adrenergic blocking agent, on aconitine-induced atrial and ouabain-induced ventricular arrhythmias in dogs. The Japanese Journal of Pharmacology 29.6 (1979): 935-945.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  36556-75-9