Recombinant Human SDF-1 Beta/CXCL12 Beta protein

• Background:

  CXCL12 also known as SDF-1 is belonging to the CXC chemokine family. It is encoded by the CXCL12 gene. In recently study, Human CXCL12 is expressed as six isoforms that differ only in the C-terminal tail. And all SDF-1 isoforms undergo proteolytic processing of the first two N-terminal amino acids. In all SDF-1 isoforms, SDF-1β is the canonical sequence. It has the complete amino acids in the C-terminal tail. On the cell surface, the receptor for this chemokine is CXCR4 and syndecan4. CXCL12 is strongly chemotactic for T-lymphocytes, monocytes, but not neutrophils. CXCL12 is a very important factor in carcinogenesis and the neovascularisation linked to tumor progression.

• Reconstitution:

  Lyophilized from a .2 μm filtered solution of PBS, pH7.4.

• Molecular Weight:

  Approximately 8.5 kDa, a single non-glycosylated polypeptide chain containing 72 amino acid residues.

• CAS Number:

  9000-83-3