Recombinant Mouse MCP-5/CCL12 protein

• Background:

  Mouse CCL12 is belonging to the CC chemokine family. It shows 66 % amino acid sequence identity to human MCP-1. CCL12 has been shown to be a potent chemoattractant for monocytes and lymphocytes but not neutrophils. At high concentrations, it will also chemoattract eosinophils. CCL12 can induce a calcium flux in human HEK-293 cells transfected with Mouse CCR2, but can not induce a calcium flux in HEK-293 cells transfected with CCR1, CCR3, or CCR5. That shows the functional receptor of CCL12 is CCR2.

• Reconstitution:

  Lyophilized from a .2 μm filtered concentrated solution in 2 mM PB, pH 7.4, 15 mM NaCl.

• Molecular Weight:

  Approximately 9.3 kDa, a single non-glycosylated polypeptide chain containing 82 amino acids.

• CAS Number:

  9000-83-3