Recombinant Mouse PF-4/CXCL4 protein

• Background:

  CXCL4 (PF4) is a small cytokine belonging to the CXC chemokine family and it is also known as chemokine (C-X-C motif) ligand 4 (CXCL4). This chemokine is released from alpha-granules of activated platelets during platelet aggregation and neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. CXCL4 interacts with a splice variant of the chemokine receptor CXCR3. Recombinant mouse CXCL4 contains 76 amino acids which is a single non-glycosylated polypeptide chain. Specifically, Human and mouse CXCL4 share about a 60 % identity.

• CAS Number:

  9000-83-3

• Reconstitution:

  Supplied as a .2 μm filtered solution of 2mM HEPES, 15mM NaCl, pH 7..

• Molecular Weight:

  Approximately 8.2 kDa, a single non-glycosylated polypeptide chain containing 76 amino acids.