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Recombinant Rat MIF protein

CAT: 0772-CD00088Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0772-CD00088Size:10 µg
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Background
Macrophage migration inhibitory factor (MIF or MMIF), also named as glycosylation-inhibiting factor (GIF), L-dopachrome isomerase, or phenylpyruvate tautomerase, is a protein encoded by the MIF gene. It is released from white blood cells by bacterial antigen stimulation to trigger an acute immune response, or by glucocorticoids to counter-act the inhibitory effects of glucocorticoids on immune system. MIF is a homotrimer of which each subunit contains 115 amino acids. As mentioned above, MIF is involved in the innate immune response to bacterial pathogens and counter-acts the anti-inflammatory activity of glucocorticoids. Furthermore, it also plays a role as mediator in regulating the function of macrophages in host defense and has phenylpyruvate tautomerase and dopachrome tautomerase activity in vitro. Rat MIF is 99 %, 90 %, 89 %, and 89 % a.a. identical to human, Mouse, porcine and bovine, respectively.
CAS Number
9000-83-3
Molecular Weight
Approximately 12.5 kDa, a single non-glycosylated polypeptide chain containing 115 amino acids.