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Recombinant Rhesus Macaque IL-13

CAT: 0772-CD00039-01Size: 2 µgDry Ice: NoHazardous: No
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CAT#:0772-CD00039-01Size:2 µg
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Background
Interleukin-13 (IL-13) is expressed by the IL13 gene and secreted by many cell types, especially T helper type 2 (Th2) cells. The high solution from of IL-13 reported to be a monomer with two internal disulfide bonds that contribute to a bundled four α-helix configuration. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Mature rhesus IL-13 shares 94%, 58%, and 60% amino acid sequence identity with human, mouse, and rat IL-13, respectively.
CAS Number
9000-83-3
Molecular Weight
Approximately12.6 kDa, a single non-glycosylated polypeptide chain containing 114 amino acids.

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