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Dovitinib

CAT: 1299-RM-D222000-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:1299-RM-D222000-01Size:10 mg
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CAS Number
915769-50-5
Synonyms
4-Amino-5-fluoro-3-[6- (4-methyl-1-piperazinyl) -1H-benzimidazol-2-yl]-2 (1H) -quinolinone 2-hydroxypropanoate hydrate (1 :1 :1)
Molecular Formula
C24H29FN6O5
Molecular Weight
500.52
Target Alternative Name
Dovitinib
Product Name Synonym
4-Amino-5-fluoro-3-[6- (4-methyl-1-piperazinyl) -1H-benzimidazol-2-yl]-2 (1H) -quinolinone 2-hydroxypropanoate hydrate (1 :1 :1)

Chemical Information

Tki258

Dovitinib Lactate is the orally bioavailable lactate salt of a benzimidazole-quinolinone compound with potential antineoplastic activity. Dovitinib strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. The activation of FGFR3 is associated with cell proliferation and survival in certain cancer cell types.

CAS Number915769-50-5
PubChem CID135611162
IUPAC Name4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one;2-hydroxypropanoic acid;hydrate
Molecular FormulaC24H29FN6O5
Molecular Weight500.5
Topological Polar Surface Area149
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count10
Rotatable Bond Count3
Heavy Atom Count36
Formal Charge0
Complexity737
SMILES
CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N.O
InChI
InChI=1S/C21H21FN6O.C3H6O3.H2O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29;1-2(4)3(5)6;/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29);2,4H,1H3,(H,5,6);1H2
InChIKey
QDPVYZNVVQQULH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tki258
CAS: 915769-50-5
CID: 135611162
Formula: C24H29FN6O5
MW: 500.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight500.5
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count10
Rotatable Bond Count3
Exact Mass500.21834621
Monoisotopic Mass500.21834621
Topological Polar Surface Area149 Ų
Heavy Atom Count36
Formal Charge0
Complexity737
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-50905-01Dovitinib
WZB81984-01Dovitinib-d8
T7104-01Dovitinib lactate
A11411-100Dovitinib 100mg
MBS5819600Dovitinib-RIBOTAC
E1KS1018Dovitinib (TKI258)
A11411-25Dovitinib 25mg

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