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Recombinant Mouse CXCL12

CAT: 0436-6508Size: 5 µgDry Ice: NoHazardous: No
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CAT#:0436-6508Size:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The C-X-C motif chemokine CXCL12 binds to one single chemokine receptor, CXCR4, to mediate cell-type specific physiological processes, including cellular migration, survival, and apoptosis. CXCL12 and its receptor CXCR4 play a role in many different diseases, including cancer, HIV, and rheumatoid arthritis. Mouse CXCL12 Recombinant Protein is purified CXCL12 produced in yeast.
Synonyms
Mouse ; CXCL12
Label
ICT
Type
Recombinant Protein
Source
Yeast
Sequence
GKPVSLSYRC PCRFFESHIA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALNKG RREEKVGKKE KIGKKKRQKK RKAAQKRKN (99)
Assay Protocol
The Mouse BAFF protein can be used in cell culture, as a BAFF ELISA Standard, and as a Western Blot Control.
Form
Lyophilized
Shipping Conditions
Shipping: Ships at ambient temperature, Ships overnight (domestic), International Priority Shipping
Storage Temperature
-20°C
Notes
20% discount
Calculated Molecular Weight
11.6 kDa
Target Description
CXCL12 was originally described as a vital chemoattractant for B cells and monocytes. CXCL12, also known as interleukin-8, is unlike other chemokines in that it binds to one single chemokine receptor, CXCR4, which itself is recognized by no other chemokines. CXCL12 binds to its receptor CXCR4 to mediate cell-type specific physiological processes, including cellular migration, survival, and apoptosis. CXCL12 is produced physiologically in various tissues, and its receptor CXCR4 is expressed on various haematopoietic and non-haematopoietic cells. CXCL12 and CXCR4 are essential for life as mice deficient in either gene are unable to survive much past birth. CXCL12 and CXCR4 play a role in many different diseases, including cancer, HIV, and rheumatoid arthritis.

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