Mouse CXCL12 Recombinant Protein

• Description:

  The C-X-C motif chemokine CXCL12 binds to one single chemokine receptor, CXCR4, to mediate cell-type specific physiological processes, including cellular migration, survival, and apoptosis. CXCL12 and its receptor CXCR4 play a role in many different diseases, including cancer, HIV, and rheumatoid arthritis. Mouse CXCL12 Recombinant Protein is purified CXCL12 produced in yeast.

• Synonyms:

  Stromal cell-derived factor 1; SDF-1; 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; TPAR1; C-X-C motif chemokine 12; Pre-B cell growth-stimulating factor; PBSF; Thymic lymphoma cell-stimulating factor; TLSF; Cxcl12; Sdf1

• Gene Name:

  CXCL12

• UniProt:

  P40224

• Tissue Specificity:

  Highest expression levels detected in kidney, liver, spleen and muscle. Isoform Alpha is expressed ubiquitously but at varying levels, while isoform Beta displays tissue-specific expression, with expression detected in kidney, liver, heart, spleen and muscle but not in lung, colon, brain, skin and stomach.

• Source:

  Yeast

• Sequence:

  [object Object]

• Applications:

  Cell Culture

• Field of Research:

  Chemokines, Host-Virus Interaction, Immunology, Innate Immunity, Interspecies Interaction, Microbiology

• Purification:

  Ion-exchange chromatography.

• Bioactivity:

  In testing.

• Form:

  Lyophilized

• Function:

  Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity) . Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

• Subcellular Location:

  Secreted.