NSC1011

CAT: 0804-HY-122079Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-122079Size:1 Each
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Description
NSC1011 is a potent Ras converting enzyme 1 endoprotease (Rce1) inhibitor with an IC50 value of 6.9 µM for HsRce1 (crystal structure of the human Rce1) . NSC1011 induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras[1].
CAS Number
[5335-97-7]
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc1011.html
Smiles
O=C(C1=CC=C(C=C1)NC(C2=CC=CC=C2)C3=CC=C4C=CC=NC4=C3O)O
Molecular Formula
C23H18N2O3
Molecular Weight
370.40
References & Citations
[1]Mohammed I, et al. 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells. Bioorg Med Chem. 2016 Jan 15;24 (2) :160-78.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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