NSC81111

CAT: 0804-HY-144441Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-144441Size:1 Each
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Description
NSC81111 is a potent and orally active EGFR-TK inhibitor with an IC50 of 0.15 nM. NSC81111 has anticaner effects[1].
CAS Number
[1678-14-4]
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc81111.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(C2=CC=C(OC)C=C2)OC(C3=CC=C(OC)C=C3)=C1
Molecular Formula
C19H16O4
Molecular Weight
308.33
References & Citations
[1]Nattanan Jiwacharoenchai, et al. Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation. Bioorg Med Chem Lett. 2022 Feb 15;58:128524.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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