Triptolide (Standard)

CAT: 0804-HY-32735R-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-32735R-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Triptolide (Standard) is the analytical standard of Triptolide. This product is intended for research and analytical applications. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[1][2][3][4][5][6].
CAS Number
[38748-32-2]
Product Name Alternative
PG490 (Standard)
UNSPSC
12352005
Hazard Statement
H300-H330-H361
Target
Apoptosis; NF-κB; Reference Standards
Type
Reference compound
Related Pathways
Apoptosis; NF-κB; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/triptolide-standard.html
Purity
99.86
Smiles
C[C@@]12[C@@]34[C@](O5)([C@@H]([C@](O6)(C(C)C)[C@@H]6[C@@H]3O4)O)[C@@H]5C[C@@]1([H])C7=C(C(OC7)=O)CC2
Molecular Formula
C20H24O6
Molecular Weight
360.40
Precautions
P260-P264-P270-P271-P280-P284-P403+P233-P405-P501
References & Citations
[1]Ganguly S, et al. Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia. Oncotarget. 2015 Oct 13;6 (31) :31767-79.|[2]Huang M, et al. Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway. Mol Cancer Ther. 2013 Feb;12 (2) :184-94.|[3]Xu P, et al. Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta25-35 via the Autophagy Pathway. PLoS One. 2015 Nov 10;10 (11) :e0142719.|[4]Kong LL, et al. Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice. Sci Rep. 2015 Jul 2;5:11747.|[5]Zhang W, et al. Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism. Int J Mol Sci. 2016 Dec 19;17 (12) . pii: E2139.|[6]Cai J, et al. Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ. J Exp Clin Cancer Res. 2021;40 (1) :190. Published 2021 Jun 9.|[7]Ganguly S, et al. Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia. Oncotarget. 2015 Oct 13;6 (31) :31767-79.|[8]Huang M, et al. Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway. Mol Cancer Ther. 2013 Feb;12 (2) :184-94.|[9]Xu P, et al. Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta25-35 via the Autophagy Pathway. PLoS One. 2015 Nov 10;10 (11) :e0142719.|[10]Kong LL, et al. Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice. Sci Rep. 2015 Jul 2;5:11747.|[11]Zhang W, et al. Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism. Int J Mol Sci. 2016 Dec 19;17 (12) . pii: E2139.|[12]Cai J, et al. Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ. J Exp Clin Cancer Res. 2021;40 (1) :190. Published 2021 Jun 9.
Shipping Conditions
Blue Ice
Storage Conditions
4°C, sealed storage, away from light and moisture, under nitrogen
Scientific Category
Reference Standards

Related Products

CatalogName
HY-32735-01Triptolide
HY-158090-01Triptolide palmitate
HY-32735STriptolide-d3
HY-177884Triptolide-6-β-D-glucose
HY-W654377Triptolide-d3 (major) (>90%)
HY-32736RTriptonide (Standard)
HY-177903Triptolide-6-succinate-β-D-glucose
HY-177885Triptolide-6-methoxy-β-D-glucose
HY-174304-01Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide
HY-15030R-01Naproxen (Standard)

Alternative Products

CatalogName
JH680114Triptolide

Popular Products