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Triptolide-6-succinate-β-D-glucose

CAT: 0804-HY-177903Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-177903Size:1 Each
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Description
Triptolide-6-succinate-β-D-glucose (Compound 2) is a glucose-conjugated derivative of Triptolide. Triptolide-6-succinate-β-D-glucose is a tumor-selective prodrug targeting glucose transporters (GLUT). Triptolide-6-succinate-β-D-glucose can induce the degradation of the RPB subunit of RNA polymerase II. Triptolide-6-succinate-β-D-glucose inhibits the proliferation of HEK293T cells with an IC50 value of 268 nM. Triptolide-6-succinate-β-D-glucose can be used for the research of cancer, such as prostatic cancer[1].
CAS Number
2003231-25-0
UNSPSC
12352005
Target
DNA/RNA Synthesis; Drug Derivative; GLUT
Related Pathways
Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
[H][C@]1(O[C@@]12[C@H](OC(CCC(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=O)=O)[C@@]4(C(C)C)O[C@@]54[H])C[C@]6(C(CO7)=C(CC[C@]6(C)[C@]82O[C@]85[H])C7=O)[H]
Molecular Formula
C30H38O14
Molecular Weight
622.61
References & Citations
[1]He QL, et al. Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation. Angew Chem Int Ed Engl. 2016 Sep 19;55 (39) :12035-9. doi: 10.1002/anie.201606121
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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