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Pipobroman

CAT: 0804-HY-16398-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16398-01Size:100 mg
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Description
Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al[1].
CAS Number
54-91-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA Alkylator/Crosslinker; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Pipobroman.html
Concentration
10mM
Purity
99.81
Solubility
DMSO : ≥ 36 mg/mL
Smiles
O=C(N1CCN(C(CCBr)=O)CC1)CCBr
Molecular Formula
C10H16Br2N2O2
Molecular Weight
356.05
Precautions
H302, H315, H319, H335
References & Citations
[1]Jean-Jacques Kiladjian, et al. Treatment of polycythemia vera with hydroxyurea and pipobroman: final results of a randomized trial initiated in 1980. J Clin Oncol. 2011 Oct 10;29 (29) :3907-13.|[2]Charles Cassius, et al. Association of Vemurafenib and Pipobroman Enhances BRAF-CRAF Dimerization in Squamous Cell Carcinoma. J Invest Dermatol. 2016 Jun;136 (6) :1302-1305.|[3]Yellin TO. Effects of piposulfan (Ancyte) on protein and DNA synthesis in Ehrlich ascites carcinoma. Life Sci II. 1971 Jun 8;10 (11) :605-12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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