SDHB Polyclonal Antibody

• Background:

  Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

• Synonyms:

  CWS2, DHSB, Ip, Iron sulfur subunit, Iron sulfur subunit of complex II, Iron-sulfur subunit of complex II, mitochondrial, PGL 4, PGL4, SDH 1, SDH, SDH1, SDH2, SDH2, homolog of, SdhB, SDHIP, Succinate dehydrogenase [ubiquinone] iron sulfur protein mitochondrial, Succinate dehydrogenase [ubiquinone] iron sulfur subunit, Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, Succinate Dehydrogenase 1 Iron Sulfur Subunit, Succinate Dehydrogenase 2, S. cerevisiae, homolog of, Succinate dehydrogenase complex iron sulfur subunit B, Succinate dehydrogenase complex subunit B iron sulfur, Succinate Dehydrogenase Complex Subunit B Iron Sulfur Protein, succinate dehydrogenase complex, subunit B, iron sulfur (Ip), Succinate dehydrogenase iron sulfur protein

• Swiss Prot:

  P21912

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant Human SDHB protein expressed by E.coli

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Applications:

  IHC

• Purification:

  Affinity purification

• Concentration:

  1 mg/mL

• Dilution:

  IHC 1:75-1:150

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH 7.4

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.