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Notch1 Polyclonal Antibody

CAT: 0866-RD90166A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD90166A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.
Description
This is a Notch1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
AOS5, AOVD1, TAN1, hN1, NOTCH1, Activated NOTCH1, notch 1
Gene ID
4851
Swiss Prot
P46531
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human Notch1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000, IF 1:50-1:200
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
129kDa
Observed Molecular Weight
140kDa
Host or Source
Rabbit
Isotype
IgG

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