NOTCH3 Polyclonal Antibody

• Background:

  This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) .

• Description:

  This is a NOTCH3 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  NOTCH3, CADASIL, CADASIL1, CASIL, IMF2, LMNS, notch 3

• Gene ID:

  4854

• Swiss Prot:

  Q9UM47

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human NOTCH3 (NP_000426.2) .

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  IHC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  IHC 1:50-1:200

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Host or Source:

  Rabbit

• Isotype:

  IgG