NOTCH4 Polyclonal Antibody

• Background:

  This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

• Description:

  This is a NOTCH4 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  NOTCH4, INT3, notch 4

• Gene ID:

  4855

• Swiss Prot:

  Q99466

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human NOTCH4 (NP_004548.3) .

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  39 kDa/61 kDa/209 kDa

• Observed Molecular Weight:

  88 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG