DuP 734

DuP 734

• CAS Number: 135135-87-4
• UNSPSC Description: DuP 734 is a sigma receptor antagonist. DuP 734 is a selective and potent sigma and 5-HT2 receptor ligand with weak affinity for D2 receptors. DuP 734 may have antipsychotic activity without the liability of motor side effects typical of neuroleptics[1][2][3].
• Target Antigen: Sigma Receptor
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/dup-734.html
• Smiles: FC1=CC=C(C(CC2CCN(CC3CC3)CC2)=O)C=C1.[H]Br
• Molecular Weight: 356.27
• References & Citations: [1]L Cook, et al. DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'- Oxoethyl)piperidine HBr], a Potential Antipsychotic Agent: Preclinical Behavioral Effects. J Pharmacol Exp Ther. 1992 Dec;263(3):1159-66.|[2]M Watanabe, et al. [³H]1-(cyclopropylmethyl)-4-(2-(4-fluorophenyl)-2-oxoethyl) Piperidine HBr (DuP 734). A Selective Ligand for Sigma Receptors in Mouse Brain in Vivo. J Pharmacol Exp Ther. 1993 Sep;266(3):1541-8.|[3]R P Kapil, et al. Dose and Species Dependent Pharmacokinetics of a Novel Sigma Receptor Antagonist, DuP 734. Res Commun Mol Pathol Pharmacol. 1995 Apr;88(1):3-20.
• Shipping Conditions: Room Temperature