PCBP2 Polyclonal Antibody

• Background:

  The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly (rC) -binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2) . Multiple transcript variants encoding different isoforms have been found for this gene.

• Description:

  This is a PCBP2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  PCBP2, HNRNPE2, HNRPE2, hnRNP-E2

• Gene ID:

  5094

• Swiss Prot:

  Q15366

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human PCBP2 (NP_001122383.1) .

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC, IF

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  33 kDa/34 kDa/35 kDa/38 kDa

• Observed Molecular Weight:

  39 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG