PCBP2 Polyclonal Antibody

• Background :

  The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly (rC) -binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2) . Multiple transcript variants encoding different isoforms have been found for this gene.

• Description :

  This is a PCBP2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  PCBP2, HNRNPE2, HNRPE2, hnRNP-E2

• Gene ID :

  5094

• Swiss Prot :

  Q15366

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein of human PCBP2 (NP_001122383.1) .

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB, IHC, IF

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1 mg/mL

• Dilution :

  WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions :

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  33 kDa/34 kDa/35 kDa/38 kDa

• Observed Molecular Weight :

  39 kDa

• Host or Source :

  Rabbit

• Isotype :

  IgG