PCBP2 Polyclonal Antibody

CAT: 0866-RD82668A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD82668A-01Size:60 μL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly (rC) -binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2) . Multiple transcript variants encoding different isoforms have been found for this gene.
Description
This is a PCBP2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
PCBP2, HNRNPE2, HNRPE2, hnRNP-E2
Gene ID
5094
Swiss Prot
Q15366
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human PCBP2 (NP_001122383.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
33 kDa/34 kDa/35 kDa/38 kDa
Observed Molecular Weight
39 kDa
Host or Source
Rabbit
Isotype
IgG

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