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HLA-DQA1 Polyclonal Antibody

CAT: 0866-RD82575A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD82575A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages) . The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
Description
This is a HLA-DQA1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
HLA-DQA1, CELIAC1, DQ-A1, HLA-DQA, CD, GSE, class II
Gene ID
3117
Swiss Prot
P01909
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human HLA-DQA1 (NP_002113.2) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000 IHC 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
27 kDa
Observed Molecular Weight
28 kDa-37KD
Host or Source
Rabbit
Isotype
IgG

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