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HLA-DRB5 Polyclonal Antibody

CAT: 0866-RD218660A-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0866-RD218660A-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Description
This is a HLA-DRB5 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
DR 9, DR beta 5, DR beta 5 chain, DR beta-5, DR beta5, DR2 beta 2, DR2-beta-2, DR9, DRB5, Dw2, FLJ76359, HLA class II histocompatibility antigen, HLA class II histocompatibility antigen DR beta 5 chain, HLA class II histocompatibility antigen DRB1-9 beta chain, HLA cla
Swiss Prot
Q30154
Accession Number
BC009234
Reactivity
Human
Immunogen
Fusion protein of human HLA-DRB5
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
1.62 mg/mL
Dilution
IHC 1:40-1:200, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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