HLA-DOB Polyclonal Antibody

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta) is a Protein Coding gene. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity. An important paralog of this gene is HLA-DRB1.

This is a HLA-DOB Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

HLA-DOB, HLA class II histocompatibility antigen, DO beta chain, MHC class II antigen DOB

P13765

NP002111

Human

Synthetic peptide of human HLA-DOB

Unconjugated

Polyclonal Antibody

WB, IHC, ELISA

Antigen affinity purification

Antibody

1.2 mg/mL

WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Store at -20°C. Avoid freeze / thaw cycles.

31 kDa

Refer to figures

Rabbit