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NR0B2 Polyclonal Antibody

CAT: 0866-RD267353A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD267353A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Description
This is a NR0B2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
NR0B2, SHP, SHP1
Gene ID
8431
Swiss Prot
Q15466
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human NR0B2 (NP_068804.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
IHC 1:50-1:200 IF 1:10-1:100
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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