UNC13B Polyclonal Antibody

• Background:

  This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.

• Description:

  This is a UNC13B Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  UNC13B, MUNC13, UNC13, Unc13h2

• Gene ID:

  10497

• Swiss Prot:

  O14795

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein of human UNC13B (NP_006368.3) .

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IF

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000 IF 1:50-1:200

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  180 kDa/182 kDa

• Observed Molecular Weight:

  210 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG