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PSENEN Polyclonal Antibody

CAT: 0866-RD266448A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD266448A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2) . Alternative splicing results in multiple transcript variants.
Description
This is a PSENEN Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
PSENEN, MDS033, MSTP064, PEN-2, PEN2
Gene ID
55851
Swiss Prot
Q9NZ42
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human PSENEN (NP_758844.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
12 kDa
Observed Molecular Weight
16 kDa
Host or Source
Rabbit
Isotype
IgG

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