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PSEN1 Polyclonal Antibody

CAT: 0866-RD82588A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD82588A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP) . These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains) . Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Description
This is a PSEN1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
AD3, FAD, PS-1, PS1, S182, Presenilin 1, PSEN1
Gene ID
5663
Swiss Prot
P49768
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human PSEN1 (NP_015557.2) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000 IHC 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
21 kDa/42 kDa/46 kDa/48 kDa/52 kDa
Observed Molecular Weight
52 kDa
Host or Source
Rabbit
Isotype
IgG

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