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KLHL3 Polyclonal Antibody

CAT: 0866-RD266137A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD266137A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D) ; a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Description
This is a KLHL3 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
KLHL3, PHA2D
Gene ID
26249
Swiss Prot
Q9UH77
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human KLHL3 (NP_059111.2) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
55 kDa/61 kDa/64 kDa
Observed Molecular Weight
75 kDa
Host or Source
Rabbit
Isotype
IgG

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